Circulating levels of glial cell line-derived neurotrophic factor in bipolar disorder: A meta-analysis of case-control studies and efficacy of therapeutic interventions

Key Points

• Circulating glial cell line-derived neurotrophic factor levels may indicate bipolar disorder severity, reflecting potential biomarkers.
• Key evidence shows fluctuating levels with significant findings across various therapeutic interventions for bipolar disorder.
• Meta-analysis approach involved reviewing case-control studies, synthesizing data to discern patterns in neurotrophic factor levels.
• This highlights the need for further research to confirm the utility of glial cell line-derived neurotrophic factor in treatment strategies.