Rational design of dual PB2/JAK2 inhibitors achieving balanced antiviral and host-directed immunomodulatory effects

Key Points

• Balance between antiviral and host-directed immunomodulatory effects is crucial for effective treatment.
• The study explores dual PB2 and JAK2 inhibitors for their potential in better therapeutic outcomes.
• Assessment focused on how these inhibitors can enhance immune response while combating viral infections.
• Findings imply the need for rational design in developing effective dual-action therapeutic agents.