Elevated serum trimethylamine N-oxide (TMAO) and trimethyllysine in patients with amyotrophic lateral sclerosis (ALS): An exploratory case–control study

Key Points

• Elevated levels of trimethylamine N-oxide and trimethyllysine were observed in patients with amyotrophic lateral sclerosis.
• The study recorded significantly higher serum TMAO and trimethyllysine levels in ALS patients compared to controls.
• Case-control analysis allowed for the identification of these biomarkers linked to the disease progression of ALS.
• This finding highlights the potential role of these biomarkers in understanding ALS mechanisms and progression.