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March 3, 2026
Metabolomic analysis of macrocyclic lactone susceptible and resistant isolates of Dirofilaria immitis
SK
Sohini Kumar
ZP
Zhiqiang Pang
ES
E A Siciliani
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Key Points
The analysis identifies distinct metabolomic profiles associated with susceptibility and resistance to macrocyclic lactones.
Key metabolites were significantly different between 10 susceptible and 10 resistant Dirofilaria immitis isolates.
Metabolomic profiling employed advanced techniques to elucidate biochemical pathways in the parasites.
Insights may inform targeted therapeutic strategies against resistant Dirofilaria immitis strains.
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Metabolomic analysis of macrocyclic lactone susceptible and resistant isolates of Dirofilaria immitis | Synapse
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Kumar et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76839badf0bb9e87e3ff9
https://doi.org/https://doi.org/10.1016/j.ijpara.2026.104803