H19 enhances pancreatic cancer proliferation and invasion by reducing miR-29c-5p’s inhibitory effects on ATF2/ECM1

Key Points

• H19 significantly enhances pancreatic cancer proliferation and invasion through the regulation of miR-29c-5p.
• Elevated levels of H19 correlate with decreased miR-29c-5p levels and increased ATF2 expression in pancreatic cancer cells.
• Analysis shows miR-29c-5p typically inhibits ATF2 and ECM1, a pathway disrupted by H19 activity.
• Findings support the need for further exploration of H19 as a potential therapeutic target in treating pancreatic cancer.