LINC01978 drives perineural invasion in cholangiocarcinoma through tumor-neural crosstalk and CCL2-mediated macrophage recruitment

Key Points

• Perineural invasion is significantly driven by linc01978 expression, influencing tumor behavior.
• High levels of ccl2 correlate with increased macrophage recruitment near perineural areas.
• This analysis utilized tumor models to demonstrate tumor-neural interactions affecting growth.
• Findings suggest that targeting linc01978 may offer new therapeutic strategies for cholangiocarcinoma.