Synergistic anti-tumor effects of paclitaxel and autophagy inhibition in drug-resistant tumors revealed by ESIPT-based NIR real-time lysosomal imaging

Key Points

• Synergistic anti-tumor effects were identified when combining paclitaxel with autophagy inhibition.
• Key evidence showed a significant reduction in tumor viability using NIR real-time lysosomal imaging methods.
• Assessment of drug-resistant tumors demonstrated enhanced drug efficacy through image-guided monitoring of lysosomal activity.
• This study may enable more effective treatments for patients with drug-resistant tumors, highlighting a need for additional clinical investigations.