Efficient hydrazide-mediated total synthesis of Möbius cyclotides from Viola japonica and elucidation of the antibacterial mechanism of Vija 31

Key Points

• Vija 31 shows significant antibacterial activity against various bacteria, indicating a promising therapeutic potential.
• Key results demonstrate that Vija 31 has a minimum inhibitory concentration of 20 µg/mL against Staphylococcus aureus.
• Synthesis utilized a hydrazide-mediated approach to efficiently create Möbius cyclotides from Viola japonica.
• Findings suggest that Vija 31’s antibacterial mechanism may involve disrupting bacterial cell membranes.