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Overcoming osimertinib resistance in NSCLC: The role of Notch1 pathway inhibition by berberine | Synapse
March 3, 2026
Overcoming osimertinib resistance in NSCLC: The role of Notch1 pathway inhibition by berberine
XJ
Xiaozhen Jiang
WX
Wen Xia
JF
Jiajia Fu
Key Points
Osimertinib resistance can be reduced by inhibiting the notch1 pathway with berberine.
Key evidence indicates that berberine treatment decreases cancer cell survival by affecting notch1 signaling.
Observational analysis across NSCLC cell lines shows a significant interaction between berberine and notch1 inhibition.
This research highlights the potential of berberine as a therapeutic agent against osimertinib resistance in lung cancer.
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Jiang et al. (Fri,) studied this question.
synapsesocial.com/papers/69a768a6badf0bb9e87e573b
https://doi.org/https://doi.org/10.1016/j.tice.2026.103365