Beyond the germ: Rethinking implant-related infections as a host–microbiota–biomaterial ecosystem

Key Points

• Infection dynamics are influenced by the interaction of host factors and biomaterials, emphasizing their ecosystem interplay.
• Significant findings include microbial communities' impact on infection severity, indicating 30% variation based on the host.
• Analysis of microbiota profiles and biomaterials was conducted to understand their collective role in infections post-implantation.
• This approach highlights the need for re-evaluation of infection prevention strategies and biomaterial design.