March 3, 2026Open Access

Association of serum cotinine with phenotypic ageacceleration and oxidative stress markers in US adults:A cross-sectional study

XMXin MaChina Meteorological Administration SBShifu BaoChengdu Fifth People's Hospital WCWanquan CaoChengdu Fifth People's Hospital

Key Points

Greater phenotypic age acceleration relates to higher serum cotinine levels, indicating health risk.
Serum cotinine levels and oxidative stress biomarkers were evaluated in a representative sample of US adults.
The observational analysis reveals a connection but does not confirm causation between the factors.
Highlighting the potential health implications, further research is needed to establish causal links.

Abstract

In this nationally representative cross-sectional study of US adults, higher serum cotinine levels were associated with greater phenotypic age acceleration. Oxidative-stress biomarkers were related to the observed association, although causal inferences cannot be drawn.

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Cite This Study

Ma et al. (Fri,) studied this question.

synapsesocial.com/papers/69a768a9badf0bb9e87e57c9 https://doi.org/https://doi.org/10.18332/tid/216136

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