What question did this study set out to answer?

This research aims to assess the effectiveness of sNGAL and NLR in identifying nephropathy in individuals with type 2 diabetes in Ghana.

March 5, 20260 citationsOpen Access

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Neutrophil Gelatinase-Associated Lipocalin and Neutrophil-to-Lymphocyte Ratio as Indicators of Nephropathy in Type 2 Diabetic Mellitus Patients in Ghana: A Case-Control Study.

AAAllwell Adofo AyirebiKumasi Technical University WBWina Ivy Ofori BoaduKwame Nkrumah University of Science and Technology STStephen TwumasiKumasi Technical University

Key Points

This research aims to assess the effectiveness of sNGAL and NLR in identifying nephropathy in individuals with type 2 diabetes in Ghana.
Conducted a case-control study comparing levels of sNGAL and NLR among type 2 diabetes patients and healthy controls.
Measured serum neutrophil gelatinase-associated lipocalin (sNGAL) and calculated neutrophil-to-lymphocyte ratio (NLR).
Analyzed the discrimination ability of both markers for diabetic nephropathy.
sNGAL demonstrated superior reliability as an indicator of nephropathy compared to NLR.
NLR showed no significant difference between groups, indicating it is not a trustworthy marker for diabetic nephropathy.
sNGAL is recommended for monitoring nephropathy in type 2 diabetes patients.

Abstract

Whiles sNGAL showed superiority and is recommended, NLR showed no significant group difference and poor, non-significant discrimination, indicating it is not a reliable standalone marker of diabetic nephropathy in this study.

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Neutrophil Gelatinase-Associated Lipocalin and Neutrophil-to-Lymphocyte Ratio as Indicators of Nephropathy in Type 2 Diabetic Mellitus Patients in Ghana: A Case-Control Study.

Key Points

Abstract

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