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Serum pepsinogen levels and Helicobacter pylori infection rates can effectively differentiate gastric cancer from benign gastric diseases, indicating their potential use in noninvasive gastric cancer screening. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

March 6, 2026Open Access

Diagnostic Value of Serum Pepsinogen and Helicobacter pylori Infection in Gastric Cancer Screening in Western Zhejiang.

Key Points

This research aims to evaluate the diagnostic value of serum pepsinogen and Helicobacter pylori infection in identifying gastric cancer.
Comparison of serum pepsinogen levels between gastric cancer patients and those with benign gastric conditions.
Assessment of Helicobacter pylori infection rates in the same groups.
Development of diagnostic models incorporating demographic data and serum pepsinogen.
Significant differences in serum pepsinogen levels were found between gastric cancer patients and those with benign diseases.
Higher rates of Helicobacter pylori infection were observed in gastric cancer patients.
Combined models showed strong diagnostic value, indicating potential for effective noninvasive gastric cancer screening.

Abstract

Serum PG expression and Hp infection rates differed between patients with GC and those with benign gastric diseases in western Zhejiang. Models combining PG with demographic variables demonstrated a good diagnostic value for GC, including EGC, supporting their potential application in noninvasive GC screening.

Diagnostic Value of Serum Pepsinogen and Helicobacter pylori Infection in Gastric Cancer Screening in Western Zhejiang.

Key Points

Abstract

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