What question did this study set out to answer?

This research aims to develop a dual-mode aptasensor for the rapid and selective detection of Cu2+.

March 6, 2026

A Dual-Mode Aptasensor Integrating Ratiometric Fluorescence and Colorimetry for On-Site Cu2+ Detection

LBLingli BuHenan University of Technology XYXia YangHenan University of Technology SQShenao QuHenan University of Technology

Key Points

This research aims to develop a dual-mode aptasensor for the rapid and selective detection of Cu2+.
Development of the RaCApt dual-mode aptasensor
Integration of ratiometric fluorescence and colorimetry
Utilization of aptamer conformational switching for detection
Achieves detection of Cu2+ in less than 5 seconds
Demonstrates high selectivity for Cu2+ over other ions
Provides dual outputs via fluorescence and colorimetric signals

Abstract

This work present RaCApt, a dual-mode aptasensor that unites ratiometric fluorescence and colorimetric readouts within a single molecular platform. Enabled by aptamer conformational switching, it achieves rapid (<5 s), selective...

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