Retrorsine impairs liver regeneration by inducing progenitor cell-senescence via ROS after partial hepatectomy.

Key Points

• The study aims to examine how retrorsine affects liver regeneration, particularly focusing on progenitor cells and cellular senescence.
• Partial hepatectomy performed on subjects.
• Administration of retrorsine to assess its impact on liver recovery.
• Evaluation of progenitor cell activity and senescence markers after surgery.
• Hepatocyte proliferation was completely suppressed by retrorsine.
• Progenitor cells exhibited minimal contribution to liver regeneration.
• Cellular senescence led to regeneration failure post-surgery.