Cardiopulmonary exercise testing revealed reduced exercise tolerance (median peak V˙O2 14.7 mL/kg/min, 63% predicted; 43% below 14 mL/kg/min threshold) in Japanese cancer patients with cardiovascular complications regardless of cardiac dysfunction status.
Observational (n=28)
No
28 Japanese patients with cancer who had concurrent cardiovascular problems (undergoing chemotherapy or had completed chemotherapy and were under regular follow-up), median age 60, 68% female.
Cardiopulmonary exercise testing (CPX) using an electronically braked cycle ergometer with breath-by-breath expiratory gas analysis.
Cardiopulmonary exercise testing parameters including peak oxygen uptake (peak VO2), anaerobic threshold (AT), ventilatory efficiency (VE vs. VCO2 slope), and maximal metabolic equivalents (METs).surrogate
Cardiopulmonary exercise testing reveals markedly reduced exercise tolerance in cancer patients with cardiovascular complications, which does not necessarily parallel left ventricular ejection fraction, highlighting the need for individualized cardio-oncology rehabilitation.
p-value: p=No significant difference between CTRCD and non-CTRCD groups in CPX parameters
Background: Despite growing interest in cardio-oncology rehabilitation (CORE), data on cardiopulmonary exercise testing (CPX/CPET) in Japanese cancer patients remain scarce.
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Asaki Saijo
Toranomon Hospital
Hidetaka Itoh
Yuko Tanabe
Toranomon Hospital
Circulation Reports
Toranomon Hospital
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Saijo et al. (Wed,) conducted a observational in Japanese adult cancer patients (median age 60, 68% female) with active cancer undergoing or post-chemotherapy and concurrent cardiovascular problems including cancer therapy-related cardiac dysfunction (CTRCD) and other cardiac conditions. (n=28). Cardiopulmonary exercise testing (CPX) was evaluated on Exercise tolerance measured by peak oxygen uptake (peak V˙O2), anaerobic threshold (AT), ventilatory efficiency (V˙E vs. V˙CO2 slope), and metabolic equivalents (METs) (p=No significant difference between CTRCD and non-CTRCD groups in CPX parameters). Cardiopulmonary exercise testing revealed reduced exercise tolerance (median peak V˙O2 14.7 mL/kg/min, 63% predicted; 43% below 14 mL/kg/min threshold) in Japanese cancer patients with cardiovascular complications regardless of cardiac dysfunction status.
synapsesocial.com/papers/69abc0de5af8044f7a4e9873 — DOI: https://doi.org/10.1253/circrep.cr-25-0331
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