Symptoms of depression and anxiety are early predictors of multi-domain disability progression in progressive MS

Key Points

• This research aims to determine if symptoms of depression and anxiety can predict disability progression in individuals with progressive MS.
• Utilized HADS scores to assess depressive and anxiety symptoms.
• Monitored disability progression over time in patients with progressive MS.
• Analyzed the relationship between symptom scores and changes in disability.
• Higher HADS scores, especially for depression, strongly predicted disability progression.
• Patient-reported outcomes showed significant prognostic value for disease worsening.