Efficacy of Low-Dose Oral Isotretinoin Combined With Fractional Microneedle Radiofrequency Versus Low-Dose Oral Isotretinoin Monotherapy in the Treatment of Moderate-To-Severe Acne Vulgaris: A Randomized Controlled Comparative Study.

Key Points

• The study aims to compare the efficacy of low-dose oral isotretinoin combined with fractional microneedle radiofrequency versus isotretinoin alone in treating moderate-to-severe acne vulgaris.
• Conducted a randomized controlled trial.
• Included participants with moderate-to-severe acne vulgaris.
• Administered low-dose oral isotretinoin to all participants.
• Combined treatment group received fractional microneedle radiofrequency.
• Analyzed treatment outcomes using standardized acne severity scales.
• The combination treatment showed greater improvements in acne severity scores compared to monotherapy.
• Participants receiving the combination therapy reported quicker resolution of lesions.
• Adverse events were comparable between both groups, indicating safety.