Exploring the Bifunctional Nature of L ‐Proline for the Organocatalytic Synthesis of 2‐Amino‐1,3,4‐thiadiazoles and 2‐Amino‐1,3,4‐oxadiazoles Under Mild Reaction Conditions

Key Points

• The aim is to explore the use of L-proline as an organocatalyst for synthesizing thiadiazoles and oxadiazoles.
• Conducted one-pot synthesis using benzothioamide and phenylformamide.
• Utilized L-proline as a naturally occurring organocatalyst.
• Employed isopropanol as a green solvent under metal-free conditions.
• Analyzed the mechanistic role of L-proline in facilitating reactions.
• Achieved moderate to high yields of 70%-92% for the target compounds.
• Demonstrated effective formation of iminium transition states.
• Established intermolecular hydrogen bonding was crucial for reaction efficiency.