VO2/t-slope is a promising diagnostic and prognostic indicator for HF, complementing VO2peak in maximal and submaximal CPET. Its proportional deterioration in HF and improvement post-exercise highlights its role in assessing functional status and disease progression. Unlike VO2peak, VO2/t-slope remains independent of CPET duration and intensity, making it particularly useful for advanced HF stages and revealing Clinical superiority. These findings support VO2/tslope as a valuable tool for HF diagnosis, classification, prognosis, and follow-up. DOI number: 10.37766/inplasy2024.9.0111, registration number INPLASY: 202490111.
Petridou et al. (Mon,) studied this question.