What question did this study set out to answer?

This research aims to evaluate management strategies for intracranial carotid artery blowout syndrome (ICABS), particularly focusing on therapeutic options.

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March 8, 2026

Therapeutic management of intracranial internal carotid artery blowout syndrome: an institutional case series and individual participant data meta-analysis

Key Points

This research aims to evaluate management strategies for intracranial carotid artery blowout syndrome (ICABS), particularly focusing on therapeutic options.
Analyzed individual participant data from a case series of ICABS cases
Used endovascular treatment (EVT) as a primary management strategy
Provided an evidence-based algorithm for guiding further management.
Conducted a systematic review to support the findings.
First-line treatment with EVT demonstrated rapid effectiveness in halting hemorrhage.
Emerging technologies showed potential for vessel-preserving strategies.
The algorithm developed serves as a guide for clinicians in managing ICABS.

Abstract

ICABS is rare and often fatal. It frequently occurs after radiation therapy for head and neck cancer or iatrogenically during transsphenoidal surgery. First-line treatment for acute ICABS is often EVT, as it offers a rapid means of halting further hemorrhage. Emerging technologies have allowed for more vessel-preserving strategies and warrant further investigation. Herein, an evidence-based algorithm is provided to help guide management. Systematic review registration no.: CRD42022385494 (www.crd.york.ac.uk/prospero/).

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Therapeutic management of intracranial internal carotid artery blowout syndrome: an institutional case series and individual participant data meta-analysis

Key Points

Abstract

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