Development of 1,2,4-oxadiazole-containing isoxazoline insecticides with improved honeybee compatibility.

Key Points

• This research aims to create insecticides that are potent against pests while being safe for honeybees.
• Identified S-(+)-L1 as a lead compound.
• Analyzed the impacts of ring-closure on molecule performance.
• Compared pesticidal potency and pollinator safety metrics.
• S-(+)-L1 shows high potency against target pests.
• Demonstrates improved compatibility with honeybees compared to traditional options.