MyoNet outperformed ResMyoNet in myocardial strain measurement from cine CMR images, achieving high consistency with reference strains (SSIM 0.961 and 0.960 for circumferential and radial strains).
Does MyoNet accurately quantify myocardial strain from cine CMR images compared to ResMyoNet and SinMod-derived reference in Dahl salt-sensitive rat models?
MyoNet provides highly accurate and efficient myocardial strain quantification from cine CMR images in preclinical models, offering a potential tool for monitoring cardiac health.
To develop and assess MyoNet, a deep learning (DL)-based network for measuring myocardial regional function from cine cardiac magnetic resonance (CMR) images, and compare its efficacy with ResMyoNet as an efficient alternative to SinMod-derived reference. MyoNet was tested alongside ResMyoNet on datasets from Dahl salt-sensitive rat models undergoing radiation therapy (RT). Both networks were designed to extract displacement maps from cine images, were specifically optimized for detailed myocardial deformation, employed advanced convolution operations with alternating kernel sizes for spatial and temporal analysis, and robust loss functions. MyoNet demonstrated superior performance in myocardial strain measurement, achieving high consistency with the SinMod-derived reference strains. It outperformed ResMyoNet, achieving higher performance metrics, including SSIM of 0.961 and 0.960, ICC of 0.973 and 0.975, and Pearson CC of 0.973 and 0.953 for circumferential (Ecc) and radial (Err) strains, respectively. Its accuracy and efficiency in generating strain measurements were validated through comprehensive statistical analyses. MyoNet offers a significant advancement in myocardial strain analysis from cine CMR images, potentially revolutionizing cardiac imaging in pre-clinical studies. Its ability to provide detailed and reliable measurements positions it as a valuable tool for clinical applications, particularly in monitoring the cardiac health of cancer patients.
An et al. (Sat,) conducted a other in Dahl salt-sensitive rat models undergoing radiation therapy. MyoNet vs. ResMyoNet was evaluated on Myocardial strain measurement (circumferential and radial strains). MyoNet outperformed ResMyoNet in myocardial strain measurement from cine CMR images, achieving high consistency with reference strains (SSIM 0.961 and 0.960 for circumferential and radial strains).