Dysregulated TMPO-AS1/let-7b-5p/PLK1/E2F1 Axis Associated with Poor Prognosis in Lung Adenocarcinoma

Key Points

• Exploring the role of the TMPO-AS1/let-7b-5p/PLK1/E2F1 regulatory axis in lung adenocarcinoma's aggressiveness and prognosis.
• Identified key regulatory components in lung adenocarcinoma samples.
• Analyzed the interactions within the TMPO-AS1/let-7b-5p/PLK1/E2F1 axis.
• Proposed therapeutic strategies targeting the regulatory network.
• The PLK1/E2F1/hsa-let-7b-5p/TMPO-AS1 axis significantly correlates with aggressive tumor behavior.
• Inhibition of TMPO-AS1 or restoration of let-7b-5p shows potential in reducing tumor aggressiveness.