Sulfones are key motifs in pharmaceuticals, agrochemicals, and functional materials, as well as versatile intermediates in synthesis. We report a general and practical protocol for sulfone synthesis that combines the group‐transfer capability of hypervalent iodine reagents (HIRs)—particularly in situ‐generated sulfonyl‐containing HIRs—with organozinc pivalates. The method delivers a broad range of sulfones in high yields under mild conditions, exhibiting excellent functional group tolerance. Importantly, the method enables efficient sulfonylation using sodium bicyclo1.1.1pentane sulfinate (BCP–SO 2 Na), providing streamlined access to functionalized BCP‐sulfones. The protocol further enables in situ sulfinate generation and one‐pot transformations. These findings expand the scope of HIR‐enabled umpolung reactivity and offer a practical, modular and operationally simple platform for accessing sulfones with broad synthetic and medicinally relevance.
Cunha et al. (Sun,) studied this question.