Hyaluronic acid-based reduction responsive nanoparticles for Improved anti-psoriasis effects of traditional Chinese herb monomer oleanolic acid via blocking YAP-AREG axis | Synapse
March 10, 2026Open Access
Hyaluronic acid-based reduction responsive nanoparticles for Improved anti-psoriasis effects of traditional Chinese herb monomer oleanolic acid via blocking YAP-AREG axis
Key Points
To investigate the effectiveness of OA-NPs@OA as a targeted therapy against psoriasis.
Developed nanoparticles using hyaluronic acid and oleanolic acid
Assessed bioavailability and safety profiles
Evaluated multimodal anti-psoriatic action
OA-NPs@OA showed significantly improved efficacy in reducing psoriasis symptoms
Enhanced bioavailability led to better therapeutic outcomes
Safety profiles were optimized compared to traditional treatments
Abstract
OA-NPs@OA represents a novel targeted nanotherapy that overcomes the limitations of OA in anti-psoriasis by offering enhanced bioavailability, multimodal anti-psoriatic action, and optimized safety profiles.