Multi-omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy.

Key Points

• This research aims to identify and characterize molecular subtypes of urothelial carcinoma (UC) to enhance precision therapy.
• Developed three UC clusters applicable for muscle-invasive bladder cancer (MIBC) and non-muscle-invasive bladder cancer (NMIBC)
• Validated clusters using transcriptomic and proteomic datasets
• Assigned publicly available UC cell lines to the clusters to create in vitro models
• Clusters exhibit distinct molecular and biological signatures
• Each cluster has unique prognostic and therapeutic characteristics