Genetic evidence for potential molecular mediators underlying the causal relationship between obesity and breast cancer: a two-step, two-sample Mendelian randomization study

Key Points

• This research aims to explore molecular mediators that connect genetically predicted BMI to breast cancer risk.
• Two-sample Mendelian randomization study design
• Analysis of genetic variants related to BMI
• Assessment of CRP levels and their association with breast cancer risk
• Higher genetically predicted BMI correlates with increased CRP levels
• CRP levels may mediate the association between BMI and breast cancer
• IGF-1 levels are identified as a potential attenuator of this relationship