What does this research mean for the field?

Acute massive copper sulfate poisoning can lead to neurological impairment and hyperglycemia, which are uncommon complications beyond the typical toxicological spectrum. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To characterize the rare complications of neurological impairment and hyperglycemia following copper sulfate poisoning.

March 13, 2026Frontiers in Medicine2 citationsOpen Access

Neurological impairment and hyperglycemia following acute copper sulfate poisoning: a case report

XZXiuqi ZhuNortheastern University HWH. WangJinhua Academy of Agricultural Sciences BSBingqiang SuJinhua Central Hospital

Key Points

To characterize the rare complications of neurological impairment and hyperglycemia following copper sulfate poisoning.
Case report of a 14-year-old girl with severe copper sulfate ingestion
Initial resuscitation and subsequent transfer to a specialized hospital for treatment
Implemented plasma exchange and chelation therapy alongside insulin for hyperglycemia
Patient developed neurological impairment and hyperglycemia as complications
Clinical symptoms improved with treatment, but some deficits remained at discharge
No recurrence of epilepsy reported, but full resolution of hyperglycemia and neurological function was not achieved

Abstract

Rationale Generally, clinical manifestations of copper sulfate intoxication include acute gastroenteritis, hemolytic anemia, and hepatorenal failure. Herein, we reported the case of a patient who developed neurological impairment and hyperglycemia following massive oral ingestion of copper sulfate. The article was to characterize these uncommon complications that extend beyond the typical toxicological spectrum, thereby enhancing the clinical understanding of copper sulfate toxicity. Patient concerns A 14-year-old girl ingested approximately 50 grams of copper sulfate. Following initial resuscitation at a local hospital, she developed rapidly progressive tachypnea and hypoxemia. She was immediately transferred to Jinhua Central Hospital for further treatment. Diagnosis The patient was diagnosed with acute severe copper sulfate intoxication, complicated by hemolytic anemia, hepatorenal failure, and two rare sequelae: neurological impairment and hyperglycemia. Interventions and outcomes The patient received gastric lavage with 15,000 mL of isotonic solution at a local hospital. Due to the subsequent deterioration of respiratory function (tachypnea and hypoxemia), she was transferred to our hospital. Based on experience from previously reported successful cases of copper sulfate poisoning, we immediately implemented a comprehensive therapeutic regimen, including plasma exchange, copper chelation therapy (sodium dimercaptopropane sulfonate combined with calcium disodium edetate), and continuous renal replacement therapy. During hospitalization, the patient developed epileptic seizures, lower extremity neurological impairment, and persistent hyperglycemia. After symptomatic treatment with neurotrophic agents and insulin for glycemic control, clinical manifestations improved, with no recurrence of epilepsy. However, hyperglycemia and lower extremity neurological dysfunction showed only partial remission and were not fully resolved at discharge. Lessons Acute massive copper sulfate poisoning may induce neurological impairment and hyperglycemia. Importantly, early monitoring and heightened vigilance for the delayed onset and protracted course of such complications are imperative.

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