Switchable electroreductive C3 or C3,C5 deuteration of imidazo1,2- a pyridines | Synapse
March 13, 2026
Switchable electroreductive C3 or C3,C5 deuteration of imidazo1,2- a pyridines
Key Points
This research aims to develop a method for selective deuteration of imidazo[1,2-a]pyridines.
Utilized D2O for electrochemical deuteration
Applied mild reaction conditions
Employed a transition-metal-free approach
Achieved selective C3 deuteration
Enabled C3,C5 dual labeling
Demonstrated high tunability in product formation
Abstract
Electrochemical deuteration enables tunable C3 or C3,C5 labeling of imidazo1,2- a pyridines using D 2 O under mild and transition-metal-free conditions.