Transcriptomic landscape of liver inflammation across time in AAV-HBV mice models

Key Points

• This research aims to analyze the transcriptomic changes in Kupffer cells during liver inflammation over time in a mouse model of Chronic Hepatitis B.
• Utilized 10x single-cell RNA sequencing (scRNA-seq) to profile Kupffer cells
• Examined transcriptomic data across different time points in the liver inflammation model
• Focused on mice models with Chronic Hepatitis B infection.
• Characterized the dynamic transcriptomic landscape of Kupffer cells during liver inflammation
• Identified specific gene expression patterns related to the inflammatory response
• Demonstrated temporal changes in Kupffer cell activity associated with disease progression.