Regioselective synthesis, structural investigation and binding behavior of 6-aroyl-7-aryl-5-methyl-4,7-dihydro-1,2,4triazolo1,5- a pyrimidines with BSA using various spectroscopic and in silico methods

Key Points

• The aim is to synthesize and characterize 6-aroyl-7-aryl-5-methyl-4,7-dihydrotriazolopyrimidines and assess their binding with BSA.
• Conducted regioselective synthesis of various triazolopyrimidines.
• Employed spectroscopic techniques for structural characterization.
• Performed in silico analyses to understand binding mechanisms.
• Compound 5t exhibited the strongest binding to BSA.
• Binding was confirmed to occur through a site I static quenching mechanism.

Abstract