A RHAMM Peptide Mimetic Reduces Capsule Fibrosis in a Novel Rodent Model of Radiation-Induced Capsular Contracture

Key Points

• To explore the effectiveness of RHAMM as a target for therapies in preventing capsular contracture after radiation.
• Developed a novel orthotopic animal model for radiation-induced capsular contracture.
• Administered RHAMM peptide mimetic to evaluate its effects on fibrosis.
• Assessed the degree of capsule fibrosis post-treatment.
• The RHAMM peptide mimetic significantly reduced capsule fibrosis in the model.
• Establishing a reproducible model allows for further investigation of preventative agents.