Organocatalytic regio-and stereoselective synthesis of chiral tetrasubstituted α-amino allenoates by γ-additions of β,γ-alkynylα-imino esters with pyrazolones

Key Points

• The aim is to develop a method for synthesizing chiral tetrasubstituted α-amino allenoates using organocatalysis.
• Utilized bis-dihydroquinine as a catalyst for nucleophilic addition
• Applied pyrazolones to β,γ-alkynyl-α-imino esters
• Focused on regio- and stereoselectivity of the synthesis
• Successfully synthesized allenylpyrazolone derivatives
• Achieved high regio- and stereoselectivity
• Confirmed the presence of adjacent quaternary stereocenters