Carriers of genetic variants related to familial hypercholesterolemia had significantly higher counts of PS+-EVs, CardioEVs, EEVs, and TFEVs compared to non-carrier family members.
Observational (n=32)
Yes
Does the presence of familial hypercholesterolemia-related genetic variants increase circulating extracellular vesicle counts compared to non-carrier family members?
Familial hypercholesterolemia is associated with increased circulating extracellular vesicles derived from cardiomyocytes and endothelial cells, suggesting their potential role as early markers of cardiovascular injury.
Effect estimate: p = 0.040 (PS+-EVs), p = 0.010 (CardioEVs), p = 0.010 (EEVs), p = 0.010 (TFEVs)
p-value: p=<0.001 (LDL-c levels)
The data suggest that EVs are related to FH and that their cellular origins could be related to cardiovascular complications commonly observed in this disease.
Silvino et al. (Wed,) conducted a observational in Familial hypercholesterolemia (n=32). Carriers of genetic variants related to familial hypercholesterolemia had significantly higher counts of PS+-EVs, CardioEVs, EEVs, and TFEVs compared to non-carrier family members.