What question did this study set out to answer?

This research aims to explore the role of the sialic acid/Siglec axis in colorectal cancer and its implications for immunotherapy.

March 13, 2026Journal for ImmunoTherapy of Cancer0 citationsOpen Access

Targeting the Sialic acid/Siglec axis: opportunities and challenges in colorectal cancer immunotherapy

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TWTe WangCentral South University CRChuixing RongHebei North University GSGaixia SunHebei North University

Key Points

This research aims to explore the role of the sialic acid/Siglec axis in colorectal cancer and its implications for immunotherapy.
Review recent findings on the sialic acid/Siglec axis
Analyze its effects on innate immune cell function
Discuss challenges in targeting this pathway in immunotherapy.
Highlight significant involvement of the sialic acid/Siglec axis in immune modulation
Identify potential benefits of targeting this axis for improved therapy outcomes
Discuss barriers to effective application in clinical settings.

Abstract

We read with great interest the recent publication by Aoise et al, titled “Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis”.

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Targeting the Sialic acid/Siglec axis: opportunities and challenges in colorectal cancer immunotherapy

Key Points

Abstract

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