Targeted Therapies in Adolescent and Young Adult Patients with Central Nervous System Tumors

Abstract Adolescent and Young Adults (AYA: ages 15-39 years) are a unique population at risk of both pediatric-type and adult-type Central Nervous System (CNS) tumors. Targeted therapies are now available for a growing subset of CNS tumors represented within AYA. Gliomas represent 25% of all primary brain tumors in AYA, with up to 30% of these harboring a pediatric-type molecular alteration in the mitogen-activated protein kinase (MAPK) pathway. MAPK pathway inhibitors are often utilized in AYA patients with a pediatric low-grade glioma (pLGG), however specific clinical trials spanning the entire AYA age range for this molecular alteration are absent. Isocitrate dehydrogenase (IDH) mutations are the most common molecular alteration found in AYA glioma. The IDH-mutant inhibitor vorasidenib has been demonstrated to prolong progression free survival (PFS) in grade 2 IDH-mutant glioma, however there is a lack of evidence in patients younger than 18. Meningioma is the most common primary CNS tumor in adults and represents 15% of primary CNS tumors in the AYA population. Recent molecular characterization of meningioma has led to several targeted therapeutic clinical trials in the relapsed/refractory setting. Medulloblastoma is the most common embryonal CNS tumor in AYA patients and is primarily driven by a mutation in the sonic hedgehog (SHH) pathway. The SHH pathway is targetable with Smoothened (SMO) inhibitors which has been utilized in the relapsed/refractory setting for both pediatric and adult patients, with mixed responses. Clinical trials incorporating SMO inhibition upfront treatment have been hampered by low accrual numbers and lack of sponsor support. Craniopharyngioma is a rare CNS tumor in the AYA population, and BRAFV600E mutations in papillary craniopharyngioma represent a targetable alteration. Solutions to improving the care of AYA should include appropriate representation in clinical trials and specialized care by experienced clinicians.