In the version of this article initially published, there was a typographical error in the Results "EAE suppresses genes related to neuronal function and survival in WT but not MIF-E22Q mice" section, where in the text now reading "BDNF and PACAP were decreased in WT EAE neurons," "decreased" appeared originally as "increased."In the second paragraph of the Methods "Tissue preparation and immunostaining" section, in the text now reading "Slices were then washed and incubated for 1 h at room temperature with the appropriate Alexa-conjugated secondary antibodies," the timing was originally shown as "2 h."In addition, there were some omissions in the Methods.In the third paragraph of the "Tissue preparation and immunostaining" section, a list of antibodies used for optic nerve staining was missing and is now included.The "Lumbar and dorsal spinal cord cell counts" heading has replaced the original "Lumbar or dorsal spinal cord neuron counts," and the following text has now been included at the end of that section: "Iba1+ microglia and Sox9+GFAP+ astrocyte densities were quantified the same way."At the end of the "Fluorescence intensity by area analysis" section, the following text has now been included: "Mean fluorescence intensity (MFI) was calculated in ImageJ for microglia and astrocyte markers in each of the full optic nerve sections."In the legend to Extended Data Fig. 3, the text "NeuN+ neuron counts in the ventral horn of the lumbar spinal cord of WT naive and MIF-E22Q naive control mice.N = 5 per genotype."has now been included.
Mace et al. (Tue,) studied this question.