MiR‐10a‐5p aggravates podocyte injury in diabetic nephropathy by inhibiting E2f7‐mediated autophagy

Key Points

• To evaluate the role of the miR-10a-5p/E2f7 axis in podocyte injury in diabetic nephropathy.
• Investigated the regulatory effects of miR-10a-5p on podocyte function and autophagy.
• Utilized in vitro and in vivo models of diabetic nephropathy.
• Applied therapeutic strategies to inhibit miR-10a-5p.
• Identified miR-10a-5p as an aggravator of podocyte injury in diabetic nephropathy.
• Demonstrated that miR-10a-5p inhibits autophagy through E2f7, worsening renal damage.
• Proposed that targeting miR-10a-5p could preserve podocyte functionality and reduce diabetic nephropathy injuries.

Abstract