Renal Adverse Events Associated With Ibuprofen Treatment After Hip and Knee Arthroplasties— A Protocol for the Preplanned Substudy of the PERISAFE Trial

Key Points

• To investigate the renal adverse events associated with ibuprofen treatment following hip and knee arthroplasties.
• Preplanned substudy within the PERISAFE trial framework
• Ethical approvals from relevant Danish agencies
• Focus on renal adverse effects post-surgery.
• Identifying potential renal complications after ibuprofen use in surgical patients.