Toxicity profile of supratherapeutic loperamide: a systematic review and dose–response analysis

Key Points

• Evaluate the toxicity and cardiac risks associated with supratherapeutic loperamide exposure.
• Conducted a systematic review of available literature on loperamide toxicity.
• Included dose-response analyses to assess the relationship between loperamide levels and cardiac events.
• Examined management strategies for patients presenting with toxicity.
• Patients with supratherapeutic loperamide levels were found to have a high incidence of life-threatening dysrhythmias.
• Close cardiac monitoring was deemed essential for this high-risk population.
• Management options identified include antiarrhythmic treatments and cardiocirculatory support.