Effect of two-year caloric restriction in the absence of malnutrition on indicators of anemia, iron status, and hepcidin in healthy adults: a randomized clinical trial

Key Points

• To examine the impact of two-year caloric restriction on iron status and hepcidin levels in healthy adults without malnutrition.
• Conducted a randomized clinical trial
• Enrolled healthy adults
• Applied caloric restriction over two years
• Monitored indicators of anemia, iron status, and hepcidin levels
• Prolonged caloric restriction did not negatively impact iron status
• Hepcidin levels remained stable throughout the trial
• No indicators of anemia were observed after two years