Folate promotes colorectal cancer progression by impairing CD8+ T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation

Key Points

• This research aims to explore how folate influences colorectal cancer and the immune system's response.
• Conducted preclinical experiments using mouse models to assess immune functions.
• Analyzed CD8+ T cell recruitment and activity in relation to folate levels.
• Investigated molecular pathways including SLC19A1, AKT, NOTCH1, and CCL5.
• Folate exposure was linked to reduced recruitment of CD8+ T cells.
• Impairments in anti-tumor activity of CD8+ T cells were observed in treated mice.
• The SLC19A1/p-AKT/NOTCH1 pathway was implicated in the observed effects.