Neutralizing autoantibodies against IFN‐α2 and IFN‐ω in a boy with a heterozygous variant in the FOXN1 gene

Key Points

• The research aims to investigate the impact of heterozygous FOXN1 variants on thymic development and autoantibody production.
• Assessment of thymic development in the affected individual.
• Identification of neutralizing autoantibodies against IFN-α2 and IFN-ω.
• Evaluation of the clinical implications of these autoantibodies in relation to viral infections.
• Impairment of thymic development linked to the FOXN1 variant.
• Selective emergence of neutralizing autoantibodies against type I IFNs.
• Increased susceptibility to severe viral infections due to the presence of these autoantibodies.