ABSTRACT Purpose To improve the quantitative accuracy of mapping in magnetic resonance fingerprinting by introducing the Dual‐MRF sequence, which alternates between FISP and PSIF acquisitions, and optimizing its parameters using estimator variance minimization. Methods The PSIF module was incorporated into the MRF sequence, resulting in the Dual‐MRF sequence with alternating signals. Furthermore, the oDual‐MRF sequence was obtained by optimizing parameters such as flip angle, repetition time, and alternation scheme using the Cramer‐Rao Bound. The performance of FISP‐MRF, Dual‐MRF, and oDual‐MRF was evaluated through simulations, phantom experiments, and in vivo studies. Results Dual‐MRF achieved higher quantification accuracy compared to conventional FISP‐MRF while maintaining accuracy. oDual‐MRF further improved accuracy without compromising map quality. Conclusion CRB‐based optimization of Dual‐MRF enhances quantification while preserving accuracy, providing a promising framework for reliable multiparametric MRF.
Li et al. (Sun,) studied this question.