Early apoptosis predicts orthodontically induced root resorption: inhibitory effects of lithium in a rat model

Key Points

• This research aims to explore the relationship between early apoptosis and orthodontically induced root resorption (OIRR) and evaluate the effects of lithium.
• Utilized a rat model to assess PDL compression and apoptosis levels during orthodontic treatment.
• Administered lithium to observe its impact on OIRR and apoptosis rates.
• Analyzed the relationship between early apoptosis and the onset of OIRR.
• Lithium significantly suppressed early apoptosis in the experimental groups.
• No changes in periodontal ligament compression were noted despite lithium treatment.
• Early apoptosis was identified as a key factor in predicting OIRR onset.