The present study aimed to develop and evaluate a herbal anti-acne cream utilising the flower extract of Millingtonia hortensis as a natural remedy for acne treatment. This study focuses on the extraction and evaluation of bioactive phytoconstituents such as saponins, alkaloids, glycosides, terpenoids, tannins, phenols and flavonoids, which are recognised for their antioxidant, antimicrobial, moisturising and skin toning properties. Additionally, the research incorporated the evaluation of antibacterial properties for the development of a stable topical product, ensuring its safety, compatibility and therapeutic effectiveness. The antioxidant potential was determined by the DPPH radical scavenging assay. The formulated cream was evaluated for physicochemical parameters, including colour, odour, pH, viscosity, spreadability, loss on drying, phase separation and stability. Invitro antibacterial activity was assessed using the well diffusion method. All formulations F6 exhibited optimum characteristics and satisfactory quality control results. The developed formulation demonstrated anti-acne activity comparable to the marketed herbal preparations, Himalaya Clarina Anti-Acne cream. It was discovered that the herbal antiacne cream formulation was stable, secure and efficient when used topically. As a promising natural source for cosmetic and dermatological preparations, Millingtonia hortensis is highlighted in the study. Additionally, the proposed formulation may be a sustainable for synthetic antibacterial compounds found in traditional goods. Keywords: Millingtonia hortensis flower, antioxidant, Anti-acne cream.Propionibacterium acne
Umesha et al. (Sun,) studied this question.