March 18, 2026

Relationship between haemodynamic and ventilatory responses in patients with diabetes mellitus

Key Result

Peak stroke volume during maximal exercise negatively correlated with minute ventilation (r=-0.59), carbon dioxide production (r=-0.53), and VO2/FC (r=-0.60) in patients with type 2 diabetes.

Key Points

To assess the relationship between functional capacity and haemodynamic responses to maximal exercise in diabetes mellitus type II patients.
Evaluated 16 patients aged around 49.4 years of both sexes
Measured peak stroke volume, cardiac output, and heart rate using cardioimpedance
Conducted incremental exercise testing on a cycle and measured pulmonary gas exchange variables
Performed data analysis including Shapiro-Wilk test for normality and Pearson correlation
Significant negative correlation between stroke volume and minute ventilation (r=-0.59)
Negative correlation between stroke volume and carbon dioxide production (r=-0.53)
Negative relationship observed between stroke volume and oxygen uptake per heartbeat (r=-0.60)

Structured PICO

What is the relationship between functional capacity and haemodynamic responses to maximal exercise in patients with type II diabetes mellitus?

Population

Patients with type II diabetes mellitus (DM-II) of both sexes, mean age 49.4±6.2 years

Intervention

Incremental exercise testing on a cycle

Outcome

Relationship between functional capacity and haemodynamic responses to maximal exercisesurrogate

In patients with type II diabetes, stroke volume performance is negatively correlated with ventilatory parameters during maximal exercise, suggesting a link between cardiovascular performance and reduced exercise capacity.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Background: Diabetes Mellitus (DM) is a chronic disease that produces negative impact of exercise capacity. Exercise tolerance has been attributed to reduced cardiovascular performance in these patients. Objective: To evaluate the relationship between functional capacity and haemodynamic responses to maximal exercise in DM-II patients. Materials and Methods: 16 patients (49.4±6.2 years) of both sexes we evaluated. Peak stroke volume (SV), cardiac output (CO) and heart rate (HR) by cardioimpedance were measured. Pulmonary gas exchange breath-by-breath was measured during an incremental exercise testing on a cycle. Peak oxygen uptake (VO 2 ), carbon dioxide production (VCO 2 ), minute ventilation (V E ), end tidal carbon dioxide tension (P et CO 2 ) and V E /VCO 2 were compared. Data analysis was used to test for normality Shapiro-Wilk test and Pearson correlation. Results: Significant and negative correlation was observed between SV with V E (r=-0.59), VCO 2 (r=-0.53) and VO 2 /FC (r=-0.60). Conclusion: The results suggest that SV performance is related to exercise capacity in diabetic individuals. These changes would be the harbinger of reduced exercise capacity in diabetics. Financial support: CNPq and FAPESP 2009/01842-0.

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