Controlled Release of Glucocorticoid via PLGA Nanoparticles for Modulating Macrophage Polarization in Inflammation Situations

Key Points

• This research aims to explore the use of PLGA nanoparticles for the controlled release of glucocorticoids to modulate macrophage polarization in inflammation.
• Developed PLGA nanoparticles for glucocorticoid encapsulation.
• Assessed macrophage polarization in response to controlled drug release.
• Evaluated the anti-inflammatory effects in vitro and in vivo.
• Demonstrated effective controlled release of glucocorticoids from PLGA nanoparticles.
• Observed modulation of macrophage polarization towards an anti-inflammatory state.
• Reduced adverse effects compared to conventional glucocorticoid treatments.

Abstract