Effects of liver-soothing and spirit-regulating acupuncture on iron metabolism in the prefrontal cortex of post-stroke depression models

Key Points

• This research aims to assess the effects of liver-soothing acupuncture on iron metabolism in models of post-stroke depression.
• Randomly assigned SD rats into sham, model, and acupuncture groups.
• Established post-stroke depression models using MCAO/R and CUMS.
• Applied acupuncture to specific points daily for 14 days.
• Conducted behavioral assessments and histological analyses of the prefrontal cortex and serum biomarker measurements.
• Acupuncture improved activity levels and reduced depressive behaviors in the model group.
• Histological observations indicated enhanced neuron morphology and decreased iron deposition in the prefrontal cortex.
• Biochemical analyses revealed significant restoration of antioxidant enzymes and reductions in oxidative stress markers post-acupuncture.